OINDPnews


Copley Scientific banner

Medical

Study links obesity to immune changes leading to asthma

A study published online December 15, 2013 in Nature Medicine shows that mice allowed to become obese develop specific immune system changes leading to airway hyper-reactivity. Researchers at Boston Children’s Hospital found that mice fed a high fat diet to the point of obesity experienced increases in IL-1β, interleukin 17A, ILC3 cells, and NLRP3 in lung cells, all … [Read more...] about Study links obesity to immune changes leading to asthma

Fresenius Kabi announces availability of acetylcysteine inhalation solution

Fresenius Kabi USA has announced the availability of 10 ml vials of 20% acetylcysteine inhalation solution. Acetylcysteine inhalation solution has been on the FDA’s drug shortage lists since 2011, in part due to a shutdown of a Luitpold facility. Fresenius Kabi launched 30 ml vials of the product in 2012. According to the current FDA drug shortage list, 10 ml vials … [Read more...] about Fresenius Kabi announces availability of acetylcysteine inhalation solution

Asmacure reports on Phase 2 trials of ASM-024 inhalation powder

Asmacure has started enrolling patients for a Phase 2 trial of its ASM-024 inhalation powder in patients with moderate and severe COPD, the company has announced. The company said that it has also completed dosing in a Phase 2 study of ASM-024 for the treatment of asthma and expects to report data early in 2014. ASM-024 has both nicotinic and muscarinic effects. … [Read more...] about Asmacure reports on Phase 2 trials of ASM-024 inhalation powder

Study shows diazepam nasal spray administered during seizure comparable to dosing after seizure

Acorda Therapeutics has presented data from a PK study of its diazepam nasal spray showing that dosing during seizure produces comparable pharmacokinetics to dosing immediately following a seizure. The company recently submitted an NDA for intranasal diazepam for the treatment of epilepsy and has said that it expects to market the product as early as 2014 if it is … [Read more...] about Study shows diazepam nasal spray administered during seizure comparable to dosing after seizure

Study shows nasal spray reduces duration of common cold symptoms

Marinomed Biotechnologie has announced that a randomized, double-blind placebo-controlled study of more than 200 patients suffering from the common cold found that patients who received a Carragelose-based nasal spray reduced the duration of symptoms by 2.1 days. Data also showed that patients' viral load was significantly reduced. The study was published in … [Read more...] about Study shows nasal spray reduces duration of common cold symptoms

Positive results for Phase 3 study of FF/VI for asthma

GlaxoSmithKline and Theravance have announced that a 12-week double-blind, parallel group Phase 3 study of their fluticasone furoate (FF)/vilanterol (VI) DPI (Breo/Relvar Ellipta) in almost 1,000 patients with moderate to severe asthma met its primary endpoint. According to the companies, both the 100/25mcg FF/VI and 200/25mcg FF/VI showed statistically significant … [Read more...] about Positive results for Phase 3 study of FF/VI for asthma

Study finds modest benefit of intranasal corticosteroids for acute sinusitis

A study by the Cochrane Acute Respiratory Infections Group examined data from four studies involving almost 2,000 patients with acute sinusitis and determined that the benefits of intranasal corticosteroids (INCS) are "modest but clinically important." According to the authors, the evidence is limited but "supports the use of INCS as a monotherapy or as an adjuvant … [Read more...] about Study finds modest benefit of intranasal corticosteroids for acute sinusitis

Positive results for Lightlake intranasal naloxone study

According to Lightlake Therapeutics, initial results from a two-week PK study of intranasal naloxone for the treatment of opioid overdose shows that the nasal spray gets naloxone into the bloodstream as fast as injection. The study, which began September 23, 2013, was conducted in conjunction with the National Institute on Drug Abuse (NIDA). Lightlake CFO Kevin … [Read more...] about Positive results for Lightlake intranasal naloxone study

Study finds out-of-hospital intranasal fentanyl safe and effective

A study by Danish researchers published online November 25, 2013 by the Annals of Emergency Medicine found that intranasal fentanyl administered by ambulance workers prior to delivery of patients to the hospital appeared to be safe and effective. The study involved over 900 patients, including adults and children older than 8, who were in severe pain. The patients … [Read more...] about Study finds out-of-hospital intranasal fentanyl safe and effective