Data from Boehringer Ingelheims ANHELTO 1 and ANHELTO 2 studies demonstrate that co-administration of the Spiriva HandiHaler tiotropium DPI and the Striverdi Respimat olodaterol SMI produced significantly greater improvement in the lung function of COPD patients than Spiriva alone. The company presented the data at CHEST 2014. The 12-week, double-blind studies … [Read more...] about BI study shows Spiriva Handihaler plus Striverdi Respimat superior to Spiriva alone
Medical
Study shows Anoro Ellipta improves lung function better than Spiriva Handihaler
Results from a 24-week study comparing GSK's Anoro Ellipta umeclidinium /vilanterol DPI to Boehringer Ingelheim's Spiriva Handihaler tiotropium DPI published in Respiratory Medicine show statistically greater improvement in trough FEV1 and weighted mean FEV1 0 – 6 hour post dose for UMEC/VI compared to tiotropium. The study involved a total of 905 COPD patients. … [Read more...] about Study shows Anoro Ellipta improves lung function better than Spiriva Handihaler
OrPro announces data from preclinical trial of inhaled thioredoxin
California-based biopharmaceutical company OrPro Therapeutics says that pre-clinical studies of its lead compound, ORP-100, an inhaled thioredoxin, has shown that ORP-100 reduces the viscosity and adhesiveness of the sputum of cystic fibrosis patients both in vitro and in vivo. No inflammation was observed in animals that received "many times the anticipated human … [Read more...] about OrPro announces data from preclinical trial of inhaled thioredoxin
Savara raises $10 million for AeroVanc development
Savara Pharmaceuticals has announced the completion of enrollment in a Phase 2 trial of its AeroVanc vancomycin DPI for the treatment of for the treatment of methicillin-resistant S. aureus (MRSA) lung infections in cystic fibrosis patients, as well as the closing of a $10 million bridge financing round for further development. In December 2013, AeroVanc received … [Read more...] about Savara raises $10 million for AeroVanc development
Verona says RPL554 could treat cystic fibrosis
Verona Pharma says that the company will present data at the upcoming North American Cystic Fibrosis Conference showing that its RPL554 inhaled PDE3/PDE4 inhibitor could be useful in treating CF. According to the company, "The presentation, entitled 'CFTR activation by the dual phosphodiesterase 3/4 inhibitor RPL554 and the MRP4 inhibitor MK571,' reports data … [Read more...] about Verona says RPL554 could treat cystic fibrosis
Monash University to develop inhaled oxytocin in partnership with GSK
Monash University will license technology related to inhaled oxytocin for the treatment of postpartum hemorrhage to to GSK, the university and GSK have announced. Monash and GSK will collaborate on development through early clinical trials, including product optimization and manufacturing process development. Development of the dry powder formulation will be funded … [Read more...] about Monash University to develop inhaled oxytocin in partnership with GSK
Invion announces completion of first feasibility studies for inhaled nadolol
According to Invion, the company has successfully completed the first stage of feasibility studies for its INV102 inhaled nadolol, which it intends to develop for the treatment of asthma, COPD, and cystic fibrosis. Invion is partnered with 3M Drug Delivery Systems for development of INV102 and INV104, inhaled zafirlukast. Nadolol is a beta blocker normally used … [Read more...] about Invion announces completion of first feasibility studies for inhaled nadolol
Mylan announces Phase 3 trial of generic fluticasone/salmeterol DPI
According to Mylan, the company will initiate a Phase 3 clinical trial of its generic version of Advair/Seretide Diskus for the treatment of asthma in October 2014, with an expected completion in April 2015. Mylan obtained global rights to the fluticasone/salmeterol inhaler from Pfizer in November 2011. Mylan CEO Heather Bresch commented, "The commencement of … [Read more...] about Mylan announces Phase 3 trial of generic fluticasone/salmeterol DPI
BI presents new data from Phase 3 studies of tiotropium/olodaterol
Boehringer Ingelheim presented data from the 5500-patient, 52-week Phase 3 TONADO studies of tiotropium/olodaterol Respimat for moderate-to-severe COPD at the 2014 ERS International Congress. BI filed an DA for tiotropium/olodaterol Respimat in August 2014. According to BI, the TONADO studies showed statistically significant improvement in lung function for … [Read more...] about BI presents new data from Phase 3 studies of tiotropium/olodaterol
Mundipharma announces new data from Flutiform pediatric study
Mundipharma presented new data from a Phase 3 study of the Flutiform fluticasone/formoterol MDI for the treatment of asthma in children aged 5 to 11 at the European Respiratory Society (ERS) Annual Congress, the company and Flutiform developer Skyepharma announced. Flutiform is not currently approved for pediatric use. The data show superiority of Flutiform … [Read more...] about Mundipharma announces new data from Flutiform pediatric study