According to Australian healthcare system Northern Health, the government of the state of Victoria will provide a $4.2 million grant to the University of Melbourne and Monash University to fund a clinical trial of intranasal heparin for the prevention and treatment of COVID-19. The Intra Nasal HEpaRin Trial (INHERIT) trial, which will be run by Northern Health, is … [Read more...] about Australian researchers get $4.2 million grant for trial of intranasal heparin for COVID-19
Medical
Aridis says its inhaled mAb candidate can neutralize all SARS-CoV-2 variants, including Omicron, plus additional coronaviruses
Aridis Pharmaceuticals said that in vitro testing has demonstrated that its AR-701 monoclonal antibody (mAb) cocktail AR-701 has the ability to neutralize all SARS-CoV-2 variants, including Omicron, as well as the coronaviruses that cause SARS, MERS, and the common cold. The company also said that AR-701 is expected to provide protection against those viruses for 6 … [Read more...] about Aridis says its inhaled mAb candidate can neutralize all SARS-CoV-2 variants, including Omicron, plus additional coronaviruses
Phase 1 trial of inhaled murepavadin gets underway
Polyphor and EnBiotix have announced the initiation of Phase 1 trial of nebulized murepavadin in healthy volunteers; Polyphor had announced approval of a Phase 1 study by the MHRA in December 2020. The murepavadin inhalation solution, which is delivered via the PARI eFlow nebulizer, is in development for the treatment of P. aeruginosa lung infections in cystic … [Read more...] about Phase 1 trial of inhaled murepavadin gets underway
Aerovate initiates Phase 2b/3 trial of AV-101 inhaled imatinib for PAH
Aerovate Therapeutics has initiated a Phase 2b/3 trial of its AV-101 imatinib DPI for the treatment of pulmonary arterial hypertension (PAH), the company said. The IMPAHCT trial is expected to enroll 462 PAH patients; the Phase 2b portion of the trial will evaluate three doses of AV-101 versus placebo to select a dose for the Phase 3 portion. Topline results from the … [Read more...] about Aerovate initiates Phase 2b/3 trial of AV-101 inhaled imatinib for PAH
ViraVac to develop intranasal COVID-19 vaccine based on Lancaster University technology
Lancaster University has announced that newly launched ViraCorp subsidiary ViraVac will develop a intranasal COVID-19 vaccine based on technology developed at Lancaster by Muhammad Munir, a lecturer in biomedicine. According to the announcement, "The company is set to announce a number of world-leading scientific partner organizations to take the vaccine through … [Read more...] about ViraVac to develop intranasal COVID-19 vaccine based on Lancaster University technology
McMaster University announces Phase 1 trial of two inhaled COVID-19 vaccines
McMaster University announced that Health Canada has cleared a Phase 1 trial of two inhaled adenovirus vector vaccines against SARS-CoV-2, and the study is set to begin shortly. The trial is expected to enroll at least 30 healthy volunteers who have already received two doses of an mRNA vaccine. Each of the participants will receive a single dose of one of the … [Read more...] about McMaster University announces Phase 1 trial of two inhaled COVID-19 vaccines
CF Foundation providing $3.5 million for development of Pulmocide’s inhaled opelconazole
The Cystic Fibrosis Foundation announced that it is providing $3.5 million for a Phase 2 study of Pulmocide Ltd's PC945 inhaled opelconazole for the prevention of pulmonary Aspergillus infections following lung transplantation. The CF Foundation noted that this is the organization's first investment in development of a drug specifically for treatment related to lung … [Read more...] about CF Foundation providing $3.5 million for development of Pulmocide’s inhaled opelconazole
Phase 3 trial of Biohaven’s intranasal zavegepant for migraine meets its primary endpoints
Biohaven Pharmaceutical said that a Phase 3 trial of its intranasal zavegepant (BHV-3500) for the treatment of moderate or severe migraine has met its primary endpoints, demonstrating statistically significant increase in freedom from both pain and most bothersome symptom compared to placebo. This is the second pivotal trial of intranasal zavegepant for migraine; in … [Read more...] about Phase 3 trial of Biohaven’s intranasal zavegepant for migraine meets its primary endpoints
FDA clears IND for Phase 2 study of Tonix’s intranasal oxytocin for the prevention of migraine
According to Tonix Pharmaceuticals, the FDA has cleared the company's IND for a Phase 2 study of TNX-1900 potentiated oxytocin nasal spray for the prevention of migraine headache. Tonix acquired the rights to the intranasal oxytocin for the treatment of migraine from Trigemina in June 2020 and says that it would plan to submit an NDA under the 505(b)(2) pathway. Over … [Read more...] about FDA clears IND for Phase 2 study of Tonix’s intranasal oxytocin for the prevention of migraine
Brigham and Women’s Hospital announces Phase 1 trial of intranasal vaccine for Alzheimer’s
Brigham and Women’s Hospital (BWH) has announced an upcoming clinical trial of an intranasal vaccine for the prevention and treatment of Alzheimer’s disease (AD). The SAD trial is expected to enroll 16 early-staged Alzheimer's patients aged 60-85 who will each get two doses of the vaccine, with the second dose administered one week following the first dose. The … [Read more...] about Brigham and Women’s Hospital announces Phase 1 trial of intranasal vaccine for Alzheimer’s