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Research finds leukotriene antagonists as effective as inhaled steroids

An article in the May 5 issue of the New England Journal of Medicine finds leukotriene-receptor antagonists (LTRAs) such as montelukast (Singulair) as effective as ICS as a first-line treatment for asthma and as effective as LABAs as an add-on for those already taking inhaled corticosteroids in real-world trials. The researchers from the University of East Anglia … [Read more...] about Research finds leukotriene antagonists as effective as inhaled steroids

Positive Phase 2 results for ISTA’s bepotastine besilate nasal spray

A Phase 2 clinical trial of its bepotastine besilate nasal spray for the treatment of seasonal allergic rhinitis has demonstrated significantly significant improvement in total nasal symptoms compared to placebo, announced ISTA Pharmaceuticals. The study involved approximately 600 patients suffering from seasonal allergy symptoms caused by mountain cedar pollen. … [Read more...] about Positive Phase 2 results for ISTA’s bepotastine besilate nasal spray

NanoBio developing intranasal vaccine to prevent urinary tract infections

The University of Michigan will license an antigen to NanoBio Corporation for development of a nasal vaccine using NanoBio's NanoStat technology for the prevention of urinary tract infections (UTIs). The antigen works by eliminating E. coli bacteria in the urinary tract. NanoBio's press release cites statistics showing that more than half of all women suffer from UTIs … [Read more...] about NanoBio developing intranasal vaccine to prevent urinary tract infections

Research shows intranasal vaccination with IL-12 highly effective

Dennis Metzger of Albany Medical College (Albany, New York) has presented research at the Society for General Microbiology Spring Conference demonstrating the effectiveness of using interleukin-12 (IL-12) in combination with intranasally-delivered vaccines to boost immune response. The study tested the effectiveness of these vaccines in mice against influenza virus, … [Read more...] about Research shows intranasal vaccination with IL-12 highly effective

Dymista 40% better than fluticasone alone in Phase 3 study

According to Meda Pharmaceuticals, a Phase 3 trial has shown that its Dymista nasal spray, a combination formulation of azelastine hydrochloride and fluticasone propionate, produced a 40% greater improvement in nasal symptoms than fluticasone alone. Meda is presenting the results at the 2011 annual meeting of the American Academy of Asthma, Allergy and Immunology … [Read more...] about Dymista 40% better than fluticasone alone in Phase 3 study

Positive results for Vectura inhaled heparin formulation

Vectura's VR496, an inhaled dry powder formulation of heparin sodium, has produced positive results in a Phase 2 study in cystic fibrosis patients, says the company. The product has received orphan drug status from both the EMA and the FDA. The study involved 77 CF patients, with 90% completing the 4-week treatment period. Patients treated with VR496 experienced … [Read more...] about Positive results for Vectura inhaled heparin formulation

Study shows tiotropium better than salmeterol for preventing COPD exacerbations

Results from the Prevention Of Exacerbations with Tiotropium in COPD (POET-COPD) study published in the New England Journal of Medicine show a significant reduction in exacerbations for COPD patients treated with tiotropium compared to those treated with salmeterol. The one-year study involved almost 7400 patients with moderate to severe COPD, half of whom were … [Read more...] about Study shows tiotropium better than salmeterol for preventing COPD exacerbations