Biotech Orgenesis and nasal delivery specialist Kurve Therapeutics have announced results from a preclinical study of an intranasal “cell-based oncolytic virus bearing product” in a mouse model of glioblastoma. Orgenesis says that it manufactured the product on behalf of “a premier cell therapy development company.” According to the companies, delivery of the product via Kurve intranasal technology resulted in a 50% reduction in brain tumors in the mice.
Orgenesis CEO Vered Caplan commented, “This is encouraging initial pre-clinical data, which demonstrates the potential of cell-based products combined with Kurve’s Controlled Particle Dispersion technology to improve the administration of CNS-related treatments. Orgenesis, through its newly formed POCare services subsidiary, has commenced clinical grade production, in collaboration with Hospital Infantil Universitario Niño Jesús in Madrid for the supply of clinical grade batches of the cell-based product intended for intravenous administration. The nasal delivery of the cell-based product has only been tested in animal models thus far. Changing the administration route of a cell-based therapy, as with any drug product, requires rigorous testing and is considered a different therapy requiring a set of pre-clinical and clinical testing according to applicable regulatory guidelines. We appreciate the tremendous support of Hospital Infantil Universitario Niño Jesús in Madrid. We also look forward to expanding our collaboration with Kurve Therapeutics.”
Kurve Therapeutics CEO Marc Giroux said, “By delivering stem cells to the brain through the blood-brain barrier, a significantly broader array of treatments could potentially be non-invasively administered. This could open a host of opportunities to treat a multitude of central nervous system (CNS)-related disorders. Over 100 CNS-related clinical trials with stem cells are ongoing or planned to start near term. Our partnership with Orgenesis and the combination of the technologies has delivered very exciting recent pre-clinical results, which could expand the possibilities for more effective stem-cell-based therapies if future clinical trials are successful.”
Read the Orgenesis press release.
