Meissa Vaccines is presenting Phase 1c data from a study of its MV-012-968 intranasal live attenuated RSV vaccine candidate in 66 children aged 6-36 months demonstrating that the highest dose of the vaccine evaluated induced an immune response in 89% of RSV-naïve subjects, with a serum neutralizing antibody response induced in 78% of the subjects. According to Meissa, the study found no serious adverse events, “negligible” viral shedding, and no difference in the rate of symptoms between the vaccine and placebo groups immediately following vaccination.
Meissa Vaccines Chief Scientific Officer Martin Moore said, “We are extremely pleased with the data from this clinical study in RSV-naïve infants and young children because Meissa’s pediatric live attenuated RSV vaccine demonstrated outstanding immunogenicity while also showing high attenuation and excellent safety. Live attenuated vaccines have historically provided broad and durable protection. These data clinically validate our AttenuBlock platform’s ability to generate live attenuated vaccines with outstanding immunogenicity and safety. Achieving both has previously been a major hurdle.”
CEO Frank Glavin commented, “The development of a safe and effective RSV vaccine is a significant global health priority that could save thousands of lives and protect the health of millions of children around the world. The clinical data we have generated from both our RSV and COVID-19 programs demonstrate the enormous potential of Meissa’s AttenuBlock platform to develop safe and effective intranasal live attenuated vaccines to protect against serious respiratory viruses, and we look forward to continuing to advance our vaccine candidates in clinical trials.”
Read the Meissa Vaccines press release.
