According to Theravance Biopharma, the first subject has been dosed in a Phase 1 clinical trial of TD-8236, a JAK inhibitor that the company is developing as a DPI for the potential treatment of asthma, COPD, and other respiratory diseases.
The company said that in preclinical studies, TD-8236 has demonstrated inhibition of JAK/STAT cytokines in disease relevant models, as well as long lung residence time and low plasma levels.
Theravance Biopharma Chief Medical Officer Brett Haumann said, “The advancement of our lung-selective JAK inhibitor program into first-in-human clinical studies is another key milestone for our research efforts in JAK inhibition and localized medicines for localized diseases. As with TD-1473, our gut-selective pan-JAK inhibitor for inflammatory intestinal diseases, we believe that TD-8236 can address key unmet needs by delivering the proven therapeutic activity of JAK inhibition to targeted tissues without immunosuppressive liabilities associated with systemic exposure. In addition to its lung-selective activity, TD-8236 offers potential utility in asthma patients regardless of Th2 phenotype. As such, we expect this compound can potentially address a very broad range of the asthma patient population, many of whom are in significant need of a treatment capable of controlling their symptoms and preventing disease exacerbations.”
Read the Theravance Biopharma press release.
